Enzymes

The Enzyme Sub-family includes: Hydrolases, Lyases, Oxidoreductases, Transferases, Isomerases, and Multiple_functions.

To have direct access to each entry in Enzyme main family, click on its uniprot id on the left bar.

Binding site feature correlation

import pandas as pd
import seaborn as sns
import matplotlib.pyplot as plt
sns.set_theme(style="whitegrid")

df_total_flat = pd.read_csv('../database/df_flattened.csv')

enzyme_df1 = df_total_flat.loc[df_total_flat['main_classs'] == "Enzymes"]
ax = sns.lmplot(
    data=enzyme_df1, x="areass", y="hpss",
    hue="sub_classs", col="sub_classs", height=3, col_wrap=3,
)
ax.set(xlabel ="Area", ylabel = "Hydrophobicity")

Binding site feature distribution

fig, axes = plt.subplots(1, 4, figsize=(9, 5))
sns.violinplot(
    y=enzyme_df1['sub_classs'],
    x=enzyme_df1['hpss'],
    hue=enzyme_df1['sub_classs'],
    ax=axes[0]
)
axes[0].set_xlabel('Hydrophobicity')
axes[0].set_ylabel('Enzyme sub-family')

sns.violinplot(
    y=enzyme_df1['sub_classs'],
    x=enzyme_df1['areass'],
    hue=enzyme_df1['sub_classs'],
    ax=axes[1]
)
axes[1].set(yticklabels=[])
axes[1].set_ylabel('')
axes[1].set_xlabel('Area')

sns.violinplot(
    y=enzyme_df1['sub_classs'],
    x=enzyme_df1['seedss_a'],
    hue=enzyme_df1['sub_classs'],
    ax=axes[2]
)
axes[2].set(yticklabels=[])
axes[2].set_ylabel('')
axes[2].set_xlabel('Alpha seeds')

sns.violinplot(
    y=enzyme_df1['sub_classs'],
    x=enzyme_df1['seedss_b'],
    hue=enzyme_df1['sub_classs'],
    ax=axes[3]
)
axes[3].set(yticklabels=[])
axes[3].set_ylabel('')
axes[3].set_xlabel('Beta seeds')

plt.tight_layout()
plt.show()