Code
import requests
import urllib3
urllib3.disable_warnings()
def fetch_uniprot_data(uniprot_id):
= f"https://rest.uniprot.org/uniprotkb/{uniprot_id}.json"
url = requests.get(url, verify=False) # Disable SSL verification
response # Raise an error for bad status codes
response.raise_for_status() return response.json()
def display_uniprot_data(data):
= data.get('primaryAccession', 'N/A')
primary_accession = data.get('proteinDescription', {}).get('recommendedName', {}).get('fullName', {}).get('value', 'N/A')
protein_name = data.get('gene', [{'geneName': {'value': 'N/A'}}])[0]['geneName']['value']
gene_name = data.get('organism', {}).get('scientificName', 'N/A')
organism
= next((comment for comment in data.get('comments', []) if comment['commentType'] == "FUNCTION"), None)
function_comment = function_comment['texts'][0]['value'] if function_comment else 'N/A'
function
# Printing the data
print(f"UniProt ID: {primary_accession}")
print(f"Protein Name: {protein_name}")
print(f"Organism: {organism}")
print(f"Function: {function}")
# Replace this with the UniProt ID you want to fetch
= "Q8NDX2"
uniprot_id = fetch_uniprot_data(uniprot_id)
data display_uniprot_data(data)
UniProt ID: Q8NDX2
Protein Name: Vesicular glutamate transporter 3
Organism: Homo sapiens
Function: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:12151341, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12151341). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12151341). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic (PubMed:33440152). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity)